Polymer Supports for Combinatorial Synthesis

With the rapid development of combinatorial synthesis in pharmaceutical industry, more specialized functional polymers are needed as supports for solid phase synthesis or as scavengers for undesired products to simplify the isolation and purification procedures. The nature of the polymer support and the functional groups is of crucial importance in such applications. Research in this area ongoing within our group focuses on the development of crosslinked polymers with high loading of various functional groups levels and with good swellability in aqueous media and in organic solvents. Moreover, large and uniform-sized polymer beads are synthesized via ascension polymerization for the one bead-one compound application in combinatorial synthesis of libraries of compounds. Some of the polymers have been tested with our collaborators in organic chemistry and in industry.